M4K3250 is a selective ALK2 PROTAC degrader with a pDC50 of 7.9. M4K3250 induces the formation of a ternary complex between ALK2 and the E3 ubiquitin ligase CRBN, thereby causing ALK2 degradation and inhibiting ALK2 activity. M4K3250 exhibits cytotoxicity in glioblastoma cells. M4K3250 can be used in studies related to glioblastoma[1].
Molecular Weight:
760.85
Formula:
C43H45FN6O6
Target:
Anaplastic lymphoma kinase (ALK),PROTACs
Application Notes:
MCE Product type: Reference compound
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