XL-20 is an orally active DNA polymerase theta (Poltheta) ATPase inhibitor with an IC50 of 4.3 nM against human targets. XL-20 activates the cGAS-STING pathway. XL-20 upregulates the expression of PD-L1 in HR-deficient cancer cells. XL-20 acts synergistically with PARP inhibition in HR-deficient cancer cells and in vivo xenograft models. XL-20 can be used in studies related to HR-deficient cancers[1].
Molecular Weight:
522.39
CAS Number:
[3082173-75-6]
Formula:
C24H18FN5O3Se
Target:
DNA/RNA Synthesis,IKK,PD-1/PD-L1,STAT,STING
Application Notes:
MCE Product type: Reference compound
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