Antibacterial agent 346 (Compound H14d) is a broad-spectrum Antibacterial agent and BsFtsZ inhibitor, with an IC50 of 69.67 µg/mL against BsFtsZ. Antibacterial agent 346 selectively binds to phosphatidylglycerol, disrupts membrane integrity, increases permeability, triggers depolarization and causes intracellular protein leakage. Antibacterial agent 346 induces intracellular ROS accumulation, which in turn triggers oxidative stress and cell death. Antibacterial agent 346 eradicates mature biofilms formed by Gram-positive and Gram-negative bacteria. Antibacterial agent 346 exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii. Antibacterial agent 346 can be used in the research of bacterial infections[1].
Molecular Weight:
602.55
Formula:
C33H35IN2O
Target:
Bacterial,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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