AChE/BChE-IN-37 is a blood-brain barrier-permeable AChE/BChE inhibitor, with an IC50 of 73.65 µM against electric eel-derived AChE and an IC50 of 82.93 µM against horse-derived BChE. AChE/BChE-IN-37 exhibits chelating activity towards Cu2+, Ca2+, Mg2+, Fe2+ and Zn2+. AChE/BChE-IN-37 interacts with HSP90AA1 and GSK-3beta. AChE/BChE-IN-37 inhibits the self-induced aggregation of Abeta1-42. AChE/BChE-IN-37 suppresses LPS-induced NO production in cells. AChE/BChE-IN-37 can be used in research related to Alzheimers disease and inflammatory diseases[1].
Molecular Weight:
432.46
Formula:
C26H22F2N2O2
Target:
Amyloid-beta,Cholinesterase (ChE),GSK-3,HSP
Application Notes:
MCE Product type: Reference compound
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