TBC1D2-IN-1 is a potent orally active and selective TBC1D2 inhibitor with a Kd of 1.1 µM. TBC1D2-IN-1 selectively inhibits TBC1D2-mediated GTP hydrolysis on RAB7A-GTP, promotes RAB7A accumulation on lysosomal membranes, and induces apoptosis and autophagy. TBC1D2-IN-1 exerts selective antiproliferative activity cancer cells. TBC1D2-IN-1 can be used for the research of cervical carcinoma[1].
Molecular Weight:
576.65
Formula:
C34H35F3N2O3
Target:
Apoptosis,Autophagy,Bcl-2 Family,Caspase
Application Notes:
MCE Product type: Reference compound
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