P2X7R antagonist-1 is an orally active P2X7 receptor antagonist with an IC50 of 3.57 µM. P2X7R antagonist-1 inhibits the proliferation, invasion and metastasis abilities of cancer cells. P2X7R antagonist-1 downregulates the expression of FAK and MMP-9. P2X7R antagonist-1 suppresses tumor growth and metastasis in a mouse breast cancer model. P2X7R antagonist-1 promotes the activation of CD4 and CD8 T cells. P2X7R antagonist-1 can be used in breast cancer-related research[1].
Molecular Weight:
453.53
Formula:
C24H31N5O4
Target:
FAK,MMP,P2X Receptor
Application Notes:
MCE Product type: Reference compound
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