PI3Kalpha-IN-33 is an orally active and selective PI3Kalpha inhibitor with an IC50 of 9.9 nM. PI3Kalpha-IN-33 blocks the PI3K/Akt/mTOR signaling pathway. PI3Kalpha-IN-33 induces apoptosis and triggers G2/M-phase arrest via Cyclin B1 and CDK1 downregulation. PI3Kalpha-IN-33 can be used for the research of colorectal cancer[1].
Molecular Weight:
377.40
Formula:
C20H19N5O3
Target:
Akt,Apoptosis,CDK,mTOR,PI3K
Application Notes:
MCE Product type: Reference compound
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