GSI526 is a IRAK4 PROTAC degrader (DC50=40.17 nM, Dmax=97%, THP-1) based on the VHL ubiquitin-proteasome system. GSI526 inhibits IRAK4-mediated NF-kappaB and MAPK inflammatory signaling pathways, and induces IRAK4 degradation in myeloid cells. GSI526 is applicable to inflammation-related research[1].
Molecular Weight:
959.17
Formula:
C51H62N10O7S
Target:
IRAK,NF-kappaB,p38 MAPK,PROTACs
Application Notes:
MCE Product type: Reference compound
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