KR-67607 is a selective 11beta-HSD1 inhibitor, with an IC50 value of 4.8 nM against h11beta-HSD1 and 7.1 nM against mouse 11beta-HSD1. KR-67607 inhibits stress-induced Glucocorticoid receptor nuclear translocation, reduces cortisol levels, suppresses the expression of ROS and proinflammatory cytokines, and enhances Nrf-2-mediated antioxidant gene transcription. KR-67607 maintains trabecular meshwork structure and reverses elevated intraocular pressure. KR-67607 improves ocular antioxidant activity and mucus secretion, reverses ocular surface damage, and prevents ischemia-reperfusion induced ocular injury. KR-67607 can be used in research related to glaucoma and dry eye disease[1][2][3].
Molecular Weight:
597.48
CAS Number:
[1401564-00-8]
Formula:
C24H29Cl2F3N4O4S
Target:
11beta-HSD,Glucocorticoid Receptor,Keap1-Nrf2,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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