BSJ-05-037 is a ITK PROTACs degrader that effectively targets and degrades ITK in T-cell lymphoma cell lines. BSJ-05-037 blocks the activation of the NF-kappaB/GATA-3 signaling pathway, inhibits PLCgamma1 phosphorylation, and reduces the proliferative capacity of T-cell lymphoma cells. BSJ-05-037 enhances the sensitivity of T-cell lymphoma cells to chemotherapy. In mouse models of T-cell lymphoma, BSJ-05-037 induces ITK degradation, reduces GATA-3 expression, decreases tumor volume, and reverses chemotherapy resistance. BSJ-05-037 is applicable to research related to T-cell lymphoma[1][2][3].
Molecular Weight:
1022.20
Purity:
98.31
CAS Number:
[2756388-01-7]
Formula:
C51H59N9O10S2
Target:
Itk,NF-kappaB,PROTACs
Application Notes:
MCE Product type: Reference compound1
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