CQ80 is a PEPD/XPNPEP1 inhibitor and selective CARD8 inflammasome activator. CQ80 has IC50 values of 0.91 µM for PEPD, 43 µM for XPNPEP1. CQ80 promotes the accumulation of Xaa-Pro peptides by inhibiting PEPD and XPNPEP1, releases the fragment of CARD8 for inflammasome formation, and induces pyroptosis via GSDMD cleavage. CQ80 can be used for research on inflammasome, CARD8-expressing cancer cells, HIV-1-infected cell clearance, acute myeloid leukemia (AML)[1].
Molecular Weight:
385.50
CAS Number:
[3034207-17-2]
Formula:
C19H35N3O5
Target:
Pyroptosis
Application Notes:
MCE Product type: Reference compound1
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