MKI-2 is a selective MASTL inhibitor with an IC50 of 37.44 nM. MKI-2 induces mitotic catastrophe resulting from the modulation of the MASTL-PP2A axis in breast cancer cells. MKI-2 reduces phospho-ENSA, total, phospho-c-Myc levels. MKI-2 inhibts cancer cells proliferation, migration and induces DNA damage. MKI-2 inhibits germinal vesicle breakdown in mouse oocytes. MKI-2 can be used for the research of cancer, such as breast cancer[1].
Molecular Weight:
381.43
CAS Number:
[438204-56-9]
Formula:
C22H19N7
Target:
c-Myc,DNA/RNA Synthesis,MASTL
Application Notes:
MCE Product type: Reference compound
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