TMPA is a high-affinity Nur77 antagonist that binds to Nur77 leading to the release and shuttling of LKB1 in the cytoplasm to activate AMPKalpha. TMPA effectively lowers blood glucose and attenuates insulin resistance in type II db/db, high-fat diet and streptozotocin-induced diabetic mice. TMPA reduces RICD (restimulation-induced cell death) in human T cells, can also be used in studies of cancer and T-cell apoptosis dysregulation[1][2].
Molecular Weight:
380.48
Purity:
98.40
CAS Number:
[1258275-73-8]
Formula:
C21H32O6
Target:
AMPK,Nuclear Hormone Receptor 4A/NR4A
Application Notes:
MCE Product type: Reference compound
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