PROTAC GSK3 degrader-1 is a potent, blood-brain barrier-permeable GSK3 PROTAC degrader, with a DC50 of 1.4 nM against GSK3beta. PROTAC GSK3 degrader-1 exerts equally potent degradation activity against both GSK3alpha and GSK3beta. It inhibits the phosphorylation of CRMP2, PRKAA1 and Tau, and stabilizes beta-catenin. PROTAC GSK3 degrader-1 can be used in the research of Alzheimers disease and Parkinsons disease[1].
Molecular Weight:
898.97
Formula:
C47H46N16O4
Target:
GSK-3,PROTACs,Tau Protein
Application Notes:
MCE Product type: Reference compound
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