Azimilide-d8 (NE-10064-d8) dihydrochloride is the deuterium labeled Azimilide dihydrochloride (HY-18600A). Azimilide dihydrochloride is a class III antiarrhythmic agent, which works by blocking potassium channels in the heart. Azimilide dihydrochloride is a dual blocker of IKs (IC50 = 2.6 µM (2mM [K]ₑ)) and IKr (IC50 = 1 µM (4 mM [K])). Azimilide dihydrochloride blocked HERG channel at 0.1 and 1 Hz with IC50s of 1.4 µM and 5.2 µM respectively. Azimilide dihydrochloride also inhibits L-type calcium current (ICa) (IC50 = 17.8 µM) and sodium current (INa) (IC50 = 19 µM). Azimilide dihydrochloride can be used for the study of atrial fibrillation and ventricular fibrillation[1][2][3][4].
