RM-046 is an orally active, selective ternary complex inhibitor of KRASQ61H (active form). RM-046 forms a ternary complex with cyclophilin A, binds to active KRASQ61H in a non-covalent manner, blocks effector binding via steric hindrance and inhibits downstream signal transduction. RM-046 inhibits ERK phosphorylation and cancer cell proliferation, and induces sustained RAS pathway signal inhibition, anti-tumor activity and tumor regression in preclinical xenograft models. RM-046 can be used for the research of KRASQ61H mutant cancers[1].
Molecular Weight:
1137.33
CAS Number:
[3058972-05-4]
Formula:
C62H79F3N8O9
Target:
Cyclophilin,ERK,Ras
Application Notes:
MCE Product type: Reference compound
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