Diclofensine, CAS [[67165-56-4]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-18610A
Supplier Catalog Number:
HY-18610A
Alternative Catalog Number:
MCE-HY-18610A-5MG,MCE-HY-18610A-10MG
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
Ro 8-4650
Diclofensine(Ro-8-4650) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively. IC50 value: Target: Dopamine reuptake inhibitor The action of diclofensine on peripheral neuronal adrenergic function was studied through tests of the blood pressure response to NE, tyramine, and phenylephrine (PE). The blood pressure response to NE was enhanced and that to tyramine was decreased by diclofensine, as a result of its inhibitive action on peripheral neuronal amine uptake [2]. Diclofensine, in concentrations of 0.01, 0.1 and 1 microM caused a marked decrease of 3H-DA uptake. In addition, it was unable to stimulate basal endogenous DA release which, on the contrary, was elicited by d-amphetamine in the same concentration (50 microM). On the other hand, diclofensine (50 microM) caused a 3 fold enhancement of K+-evoked DA release [3].
Molecular Weight:
322.23
Purity:
98.46
CAS Number:
[67165-56-4]
Formula:
C17H17Cl2NO
Target:
Dopamine Transporter
Application Notes:
MCE Product type: Reference compound
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