SB-612111 is a novel and potent opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (Ki=0.33 nM). SB-612111 exhibits selectivity for µ-, kappa- and delta-receptors with Ki values of 57.6 nM, 160.5 nM and 2109 nM, respecticely. SB-612111 effectively antagonizes the pronociceptive action of Nociceptin (HY-P0183) in an acute pain model[1].
Molecular Weight:
418.40
CAS Number:
[371980-98-2]
Formula:
C24H29Cl2NO
Target:
Opioid Receptor
Application Notes:
MCE Product type: Reference compound
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