PFI-2 ((R)-PFI-2 hydrochloride) hydrochloride, a chemical probe, is a potent and selective SET domain containing lysine methyltransferase 7 (SETD7) inhibitor. (R)-PFI-2 shows high inhibiting activity with IC50 value of 2.0 nM and (S)-PFI-2 shows inhibiting activity with IC50 value of 1.0 µM. PFI-2 hydrochloride can be used for the research of chronic kidney disease and inflammation response in the development of renal fibrosis[1][2].
Molecular Weight:
499.52
Purity:
99.68
CAS Number:
[1627676-59-8]
Formula:
C23H25F4N3O3S
Target:
Histone Methyltransferase
Application Notes:
MCE Product type: Reference compound
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