UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 µM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.
Molecular Weight:
468.34
Purity:
99.66
CAS Number:
[518303-20-3]
Formula:
C18H14BrNO5S2
Target:
Bcl-2 Family
Application Notes:
Reference compound
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