D77 is anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75. D77 inhibits HIV-1(IIIB) replication by EC50 value of 23.8 µg/ml in MT-4 cell (5.03 µg/ml for C8166 cells). IC50 value: 23.8 µg/ml (EC50, in MT-4 cell ), 5.03 µg/ml (EC50, in C8166 cell) Target: HIV-1 in vitro: D77 exhibits a highly specific binding affinity to HIV-1 integrase catalytic core domain.D77 induces a dramatic concentration-dependent decrease of alpha-galactosidase activity compared to the D77-untreated cells. D77 reveals a significant inhibition activity against the interaction of IN with IBD.
Molecular Weight:
596.45
CAS Number:
[497836-10-9]
Formula:
C28H22BrNO7S
Target:
HIV
Application Notes:
MCE Product type: Reference compound
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