SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer. Target: mTOR SMER18 induces autophagy independently of Rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein, which are associated with Huntingtons disease and familial Parkinsons disease, respectively. SMER18 acts either independently or downstream of the target of Rapamycin, attenuates mutant huntingtin-fragment toxicity in Huntingtons disease cell and Drosophila melanogaster models, which suggests therapeutic potential.
Molecular Weight:
287.74
Purity:
98.64
CAS Number:
[944153-47-3]
Formula:
C16H14ClNO2
Target:
Autophagy
Application Notes:
MCE Product type: Reference compound
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