OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 µM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3beta and myosin light chain)[1]. OSU-T315 abrogates AKT activation by impeding AKT localization in lipid rafts and triggers caspase-dependent apoptosis in an ILK-independent manner[2]. OSU-T315 causes cell death through apoptosis and autophagy[1].
Molecular Weight:
533.59
Purity:
99.88
CAS Number:
[2070015-22-2]
Formula:
C30H30F3N5O
Target:
Apoptosis,Autophagy,Integrin
Application Notes:
MCE Product type: Reference compound
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