ILK-IN-2 (OSU-T315 analog) is an oral PDK2 inhibitor and also an ILK inhibitor, with an IC50 of 0.6 µM. ILK-IN-2 induces cell autophagy and apoptosis, showing anti-tumor activity. ILK-IN-2 directly abolishes AKT activation by preventing AKT from translocating to lipid rafts, triggering Caspase-dependent apoptosis in chronic lymphocytic leukemia (CLL) and extending the lifespan in TCL1 mouse models[1][2].
Molecular Weight:
533.59
Purity:
99.41
CAS Number:
[1333146-24-9]
Formula:
C30H30F3N5O
Target:
Ser/Thr Kinase
Application Notes:
MCE Product type: Reference compound
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