TC-N 22A is a potent, selective, orally active and brain-permeable mGlu4 PAM with an EC50 of 9 nM in human mGlu4-expressing BHK cells. TC-N 22A is less active (EC50>10 µM) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors. TC-N 22A has the potential for research of CNS disease in vivo[1].
Molecular Weight:
283.35
CAS Number:
[1314140-00-5]
Formula:
C14H13N5S
Target:
mGluR
Application Notes:
MCE Product type: Reference compound
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