CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. IC50 value: 2.7 µM (EC50, for NR2C) and 2.8 µM (EC50, NR2D) Target: NMDA receptor CIQ increases channel opening frequency of recombinant NR2Cor NR2D containing receptors by two-fold (EC50 = 2.7 and 2.8 µM, respectively), with no effect on NR2A or NR2B subtypes. CIQ does not alter the EC50 values for glutamate or glycine on channel opening. CIQ increases channel opening efficiency and enhances NMDA receptor responses. CIQ reduces associated behaviours in schizophrenia models and potentially enhances dopamine release in Parkinsons disease models.
Molecular Weight:
467.94
Purity:
99.75
CAS Number:
[486427-17-2]
Formula:
C26H26ClNO5
Target:
iGluR
Application Notes:
MCE Product type: Reference compound
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