Zorifertinib (AZD3759) is a potent, orally active, central nervous system-penetrant, EGFR inhibitor. At Km ATP concentrations, the IC50s are 0.3, 0.2, and 0.2 nM for EGFRwt, EGFRL858R, and EGFRexon 19Del, respectively. Zorifertinib induces cancer cell apoptosis. Zorifertinib has antitumor activity, and can be used for NSCLC, HCC etc. research[1].
Molecular Weight:
459.90
Purity:
99.37
CAS Number:
[1626387-80-1]
Formula:
C22H23ClFN5O3
Target:
Apoptosis,EGFR
Application Notes:
MCE Product type: Reference compound
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