Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC50 values for PKCdelta of 3-6 µM, PKCalpha,beta,gamma of 30-42 µM, PKCepsilon,eta,zeta of 80-100 µM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation[1][2][3]. Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection[4][5].
Molecular Weight:
516.54
Purity:
98.45
CAS Number:
[82-08-6]
Formula:
C30H28O8
Target:
Apoptosis,Autophagy,HIV,PKC,RABV
Application Notes:
MCE Product type: Natural Products
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