CL-184005 is an antagonist for platelet-activating factor (PAF), that inhibits the PAF-induced platelet aggregation with IC50 of 600 nM and 510 nM, in human and rabbit platelet-rich plasma. CL-184005 protects the rats from endotoxin-induced gastrointestinal damage and hypotension. CL-184005 exhibits potential attenuating Gram-negative bacterial sepsis[1].
Molecular Weight:
631.76
CAS Number:
[140466-18-8]
Formula:
C33H46NO7PS
Target:
Platelet-activating Factor Receptor (PAFR)
Application Notes:
MCE Product type: Reference compound
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