SB-273005 is an orally active non-peptide alphavbeta3 integrin antagonist with Ki values of 1.2 nM and 0.3 nM for alphavbeta3 and alphavbeta5, respectively. SB-273005 blocks the binding of integrins to the RGD sequence in the extracellular matrix. SB-273005 inhibits Rictor phosphorylation and reduces IL-10 secretion. SB-273005 inhibits inflammation, prevents bone loss, regulates vascular smooth muscle function, and reverses pregnancy-induced immune deviation. SB-273005 can be used in the study of rheumatoid arthritis, osteoporosis, and aneurysms. [1][2][3][4][5].
Molecular Weight:
451.44
Purity:
99.94
CAS Number:
[205678-31-5]
Formula:
C22H24F3N3O4
Target:
Integrin,Interleukin Related
Application Notes:
MCE Product type: Reference compound
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