Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease[1].
Molecular Weight:
615.48
Purity:
99.29
CAS Number:
[1025967-78-5]
Formula:
C29H24Cl2N2O7S
Target:
Integrin
Application Notes:
MCE Product type: Reference compound
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