Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC50 of 0.72 µM (IC50 of 13.08 µM for store operated Ca2+ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels[1].
Molecular Weight:
449.37
Purity:
99.95
CAS Number:
[1315323-00-2]
Formula:
C18H13F6N3O2S
Target:
TRP Channel
Application Notes:
MCE Product type: Reference compound
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