RWJ-58643 is a beta-trypsin inhibitor that suppresses allergic inflammation. RWJ-58643 (100 mg) significantly reduced nasal allergy symptoms, eosinophil infiltration, and IL-5 levels at low doses. RWJ-58643 resulted in late eosinophilia and elevated IL-5 levels at high doses (300 mg and 600 mg). RWJ-58643 modulates allergic responses by inhibiting the release of beta-trypsin from mast cells[1].
Molecular Weight:
446.52
CAS Number:
[287183-00-0]
Formula:
C20H26N6O4S
Target:
Ser/Thr Protease
Application Notes:
MCE Product type: Reference compound
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