Upadacitinib (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib (ABT-494) can be used for several autoimmune disorders research[1][2].
Molecular Weight:
380.37
Purity:
99.98
CAS Number:
[1310726-60-3]
Formula:
C17H19F3N6O
Target:
JAK
Application Notes:
MCE Product type: Reference compound
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