EGFR-IN-1 (compound 24) is an orally active and irreversible L858R/T790M mutant selective EGFR inhibitor. EGFR-IN-1 potently inhibits Gefitinib-resistant EGFR L858R, T790M with 100-fold selectivity over wild-type EGFR. EGFR-IN-1 displays strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. Antitumor activity[1].
Molecular Weight:
514.58
CAS Number:
[1625677-63-5]
Formula:
C28H30N6O4
Target:
EGFR
Application Notes:
MCE Product type: Reference compound
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