EGFR-IN-1 TFA is an orally active and irreversible L858R/T790M mutant selective EGFR inhibitor. EGFR-IN-1 TFA potently inhibits Gefitinib-resistant EGFR L858R, T790M with 100-fold selectivity over wild-type EGFR. EGFR-IN-1 TFA displays strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. Antitumor activity[1].
Molecular Weight:
628.60
Purity:
99.38
CAS Number:
[2753348-63-7]
Formula:
C30H31F3N6O6
Target:
EGFR
Application Notes:
MCE Product type: Reference compound
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