BRD3308 is a highly selective HDAC3 inhibitor with an IC50 of 54 nM. BRD3308 is 23-fold selectivity for HDAC3 over HDAC1 (IC50 of 1.26 µM) or HDAC2 (IC50 of 1.34 µM). BRD3308 suppresses pancreatic beta-cell apoptosis induced by inflammatory cytokines or glucolipotoxic stress, and increases functional insulin release. BRD3308 activates HIV-1 transcription and disrupts HIV-1 latency[1][2][3].
Molecular Weight:
287.29
Purity:
98.34
CAS Number:
[1550053-02-5]
Formula:
C15H14FN3O2
Target:
Apoptosis,HDAC,HIV
Application Notes:
MCE Product type: Reference compound
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