BMS-561392 is a selective ADAM17(TACE) inhibitor. BMS-561392 inhibits TNF-alpha secretion by regulating signaling pathways such as p44 MAPK and NF-kappaB. BMS-561392 also affects the survival of central nervous system-related cells including oligodendrocytes and microglia. BMS-561392 promotes microglial apoptosis, enlarges the injury area and exacerbates astrogliosis in a mouse spinal cord injury model. BMS-561392 can be used in research related to spinal cord injury and inflammatory diseases[1][2].
Molecular Weight:
476.57
CAS Number:
[611227-74-8]
Formula:
C27H32N4O4
Target:
Apoptosis,NF-kappaB,p38 MAPK,TNF Receptor
Application Notes:
MCE Product type: Reference compound1
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