Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active interleukin-1beta converting enzyme (ICE, caspase 1) inhibitor with a Ki of 1.4 nM. Pralnacasan inhibits proinflammatory cytokines IL-18, IL-1beta , and IFN-gamma. Pralnacasan has the potential for osteoarthritis and rheumatoid arthritis treatment[1][2].
Molecular Weight:
523.54
Purity:
99.83
CAS Number:
[192755-52-5]
Formula:
C26H29N5O7
Target:
Caspase
Application Notes:
Reference compound
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