Ipidacrine (hydrochloride), CAS [[90043-86-0]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-19689
Supplier Catalog Number:
HY-19689
Alternative Catalog Number:
MCE-HY-19689-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
NIK-247, Amiridine
Ipidacrine (NIK-247, Amiridine) hydrochloride is orally active and blood-brain-barrier-penetrant AChE and BuChE inhibitors with IC50 values of 1 µM and 1.9 µM, respectively, which is also a partial agonist of M2-cholinergic receptors and a reversible cholinesterase inhibitor. Ipidacrine hydrochloride has a stimulating effect on neuromuscular transmission and excitation along the nerve fibres with a moderately anti-pain effect. Ipidacrine hydrochloride is an aminopyridines and is structurally similar to Tacrine (HY-111338). Ipidacrine hydrochloride is effective in various amnesia models, improves erectile function and inhibits K+ and Na+-channels in the neuronal membrane in diabetic rats. Ipidacrine hydrochloride is promising for research of Alzheimers disease, ischaemic stroke, idiopathic neuropathy of the facial nerve, diabetes mellitus-induced erectile dysfunction and other deficits in central or peripheral cholinergic deseases[1][2][3][4][5].
