HPOB is a highly potent and selective inhibitor of HDAC6 with an IC50 of 56 nM. HPOB displays >30 fold less potent against other HDACs. HPOB enhances the effectiveness of DNA-damaging anticancer agents in transformed cells but not normal cells. HPOB does not block the ubiquitin-binding activity of HDAC6[1].
Molecular Weight:
314.34
Purity:
99.80
CAS Number:
[1429651-50-2]
Formula:
C17H18N2O4
Target:
Apoptosis,HDAC
Application Notes:
Reference compound
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