I-BET282E is a pan-inhibitor of all eight BET bromodomains, and selectivity over other representative bromodomain-containing proteins. I-BET282E shows pIC50s ranging 6.4-7.7 for BRD2 (BD1/BD2), BRD2 (BD1/BD), BRD3 (BD1/BD), and BRD4 (BD1/BD)[1].
Molecular Weight:
546.64
CAS Number:
[2885162-99-0]
Formula:
C26H34N4O7S
Target:
Epigenetic Reader Domain
Application Notes:
Reference compound
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