GSK3117391 (ESM-HDAC391, CHR-5154, HDAC-IN-3) is an orally active HDAC inhibitor with a IC50 of 55 nM. Using esterase-sensitive motif technology, GSK3117391 is selectively converted into its active acid metabolite HDAC189 in cells expressing carboxylesterase-1. GSK3117391 induces sustained global protein acetylation in monocytes, inhibits the production of proinflammatory cytokines, depletes circulating monocytes, downregulates the expression of CSF1R, and inhibits monocyte adhesion and differentiation. GSK3117391 can be used in the research of chronic inflammatory diseases[1].
Molecular Weight:
403.52
Purity:
99.40
CAS Number:
[1018673-42-1]
Formula:
C22H33N3O4
Target:
c-Fms,HDAC
Application Notes:
MCE Product type: Reference compound
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