PL37 (Debio-0827) is an orally active Enkephalinase dual inhibitor (dual inhibition refers to the simultaneous inhibition of Neutral Endopeptidase and Aminopeptidase N activities). PL37 exerts its anti-hyperalgesic effects by activating µ-opioid receptors (µ-opioid receptors), with an ED50 value of 13.4 mg/kg for analgesic effects in mice. PL37 can be used to study diabetic neuropathic pain[1][2][3][4].
Molecular Weight:
518.71
CAS Number:
[935481-06-4]
Formula:
C22H34N2O6S3
Target:
Aminopeptidase,Neprilysin,Opioid Receptor
Application Notes:
MCE Product type: Reference compound
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