COTI-2, an anti-cancer agent with low toxicity, is an orally available third generation activator of p53 mutant forms. COTI-2 acts both by reactivating mutant p53 and inhibiting the PI3K/AKT/mTOR pathway. COTI-2 induces apoptosis in multiple human tumor cell lines. COTI-2 exhibits antitumor activity in HNSCC through p53-dependent and -independent mechanisms. COTI-2 converts mutant p53 to wild-type conformation[1][2][3].
Molecular Weight:
366.48
Purity:
99.02
CAS Number:
[1039455-84-9]
Formula:
C19H22N6S
Target:
Apoptosis,MDM-2/p53
Application Notes:
MCE Product type: Reference compound
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