Pifusertib (TAS-117) hydrochloride is a potent, selective, orally active allosteric Akt inhibitor (with IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). Pifusertib hydrochloride triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. Pifusertib hydrochloride induces apoptosis and autophagy[1].
Molecular Weight:
460.96
Purity:
99.90
CAS Number:
[2930090-28-9]
Formula:
C26H25ClN4O2
Target:
Akt,Apoptosis,Autophagy
Application Notes:
MCE Product type: Reference compound
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