Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor. Mirin prevents MRN-dependent activation of ATM (IC50=12 µM) without affecting ATM protein kinase activity, and it inhibits Mre11-associated exonuclease activity. Mirin abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells. Mirin prevents ATM activation in response to DNA double-strand breaks (DSBs) and blocks homology-directed repair (HDR) in mammalian cells[1][2].
Molecular Weight:
220.25
Purity:
99.63
CAS Number:
[1198097-97-0]
Formula:
C10H8N2O2S
Target:
Apoptosis,ATM/ATR
Application Notes:
MCE Product type: Reference compound
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