IITZ-02 is a lysosomotropic Autophagy inhibitor. IITZ-02 enhances autophagosome accumulation but inhibits autophagosomal degradation by impairing lysosomal function, finally inducing the inhibition of autophagy. IITZ-02 abolishes mitochondrial membrane potential and induces apoptosis through the mitochondria-mediated pathway. IITZ-02 has a potent antitumor activity in MDA-MB-231 xenograft mouse models. IITZ-02 can be used for cancers research[1].
Molecular Weight:
494.55
Purity:
96.51
CAS Number:
[1807988-46-0]
Formula:
C27H26N8O2
Target:
Apoptosis,Autophagy,Mitochondrial Metabolism
Application Notes:
MCE Product type: Reference compound1
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