T863 is an orally active, selective and potent DGAT1 (acyl-CoA:diacylglycerol acyltransferase 1) inhibitor with an IC50 of 15 nM. T863 has no inhibitory activity against human MGAT3, human DGAT2, or human MGAT2. T863 interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells[1][2].
Molecular Weight:
394.47
Purity:
99.83
CAS Number:
[701232-20-4]
Formula:
C22H26N4O3
Target:
Acyltransferase
Application Notes:
Reference compound
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