Serpin B9-IN-1 (BTCA) is an inhibitor that specifically targets Serpin B9 (SB9), SB9 is a natural inhibitor of granzyme B (GrB) , but may promote the metastasis of lung cancer cells into the bone marrow. SB9-overexpressing cancer cells promote proliferation and metastasis in an immune cell-dependent manner by binding to GrB. Inhibition of SB9 by Serpin B9-IN-1 significantly inhibits immunotherapy of lung cancer bone metastases in the caudal artery (CA) mouse model (LCBM)[1].
Molecular Weight:
163.13
Purity:
98
CAS Number:
[154235-77-5]
Formula:
C8H5NO3
Target:
Biochemical Assay Reagents
Application Notes:
MCE Product type: Biochemical Assay Reagents
* VAT and and shipping costs not included. Errors and price changes excepted
